Protein Engineering and Directed Evolution
Many challenges facing humanity can be solved if only we could efficiently and reliably engineer proteins with desired activities. There has to be a better way
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MAbs. 2014 Jan-Feb;6(1):236-45. Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity. Groves MA, Amanuel L,...
Insights into thermodynamic and informatic constraints on natural protein sequences from de novo protein design
This paper analyses insights into thermodynamic and informatic constraints on natural protein sequences based on the de novo protein design experiment. One of the conclusions argues that there could be no selection pressure against highly stable proteins...
A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction
Innate restriction factors provide potential antiviral strategies against invading pathogens such human immunodeficiency virus type 1(HIV-1). Apolipoprotein B mRNA-editing catalytic-polypeptide 3proteins (APOBEC3; A3) represent one such family of restriction factors....