Protein Engineering and Directed Evolution

Many challenges facing humanity can be solved if only we could efficiently and reliably engineer proteins with desired activities. There has to be a better way


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section 2

Under Construction




Antibody affinity improved by a deletion

MAbs. 2014 Jan-Feb;6(1):236-45. Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity. Groves MA, Amanuel L,...

A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction

Innate restriction factors provide potential antiviral strategies against invading pathogens such human immunodeficiency virus type 1(HIV-1). Apolipoprotein B mRNA-editing catalytic-polypeptide 3proteins (APOBEC3; A3) represent one such family of restriction factors....